Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse
نویسندگان
چکیده
Tasha N. Sims, Timothy J. Soos, Harry S. Xenias, Benjamin Dubin-Thaler, Jake M. Hofman, Janelle C. Waite, Thomas O. Cameron, V. Kaye Thomas, Rajat Varma, Chris H. Wiggins, Michael P. Sheetz, Dan R. Littman, and Michael L. Dustin* Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA Howard Hughes Medical Institute and Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA Department of Biological Sciences Department of Physics Department of Applied Physics and Applied Mathematics Columbia University, New York, NY 10027, USA Present address: Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. *Correspondence: [email protected] DOI 10.1016/j.cell.2007.03.037
منابع مشابه
Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.
The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and autonomous naive T cell migration. The migration phase is driven by PKCtheta, w...
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Tasha N. Sims, Timothy J. Soos, Harry S. Xenias, Benjamin Dubin-Thaler, Jake M. Hofman, Janelle C. Waite, Thomas O. Cameron, V. Kaye Thomas, Rajat Varma, Chris H. Wiggins, Michael P. Sheetz, Dan R. Littman, and Michael L. Dustin* Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA Howard Hughes Medical Inst...
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Protein kinase Cη (PKCη) is a member of the novel PKC subfamily, which also includes δ, ε, and θ isoforms. Compared to the other novel PKCs, the function of PKCη in the immune system is largely unknown. Several studies have started to reveal the role of PKCη, particularly in T cells. PKCη is highly expressed in T cells, and is upregulated during thymocyte positive selection. Interestingly, like...
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Activated T cells form stable immunological synapses with antigen-presenting cells whereas naïve T cells initially engage in more transient interactions. Sims et al. (2007) demonstrate that these transient interactions are due to the kinase PKCtheta, which serves to destabilize the synapse thereby permitting T cells to migrate elsewhere. They also show that re-establishment of a synapse involve...
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عنوان ژورنال:
- Cell
دوره 129 شماره
صفحات -
تاریخ انتشار 2007